
scenario:

# uncomment to use variable spreading
#variableSpread:        true    (or (default if not specified: false))

iterations:             1

# random generator      random, fixed, increasing   (default: random)
generator:              random

# with fixed, increasing generators: initial seed (default 1)
seed:                   1

nWomen:                 100000

#             discount                pairs of (increasing) begin-diam: cost
#         ref.age proportion  biop    (first diameter must be 0)
costs:    50      0           176     0: 6438  20: 7128  50: 7701

# screeningRound: age (space separated) type(s). 
# Types are Mammo, Tomo, MRI, see below at Modalities. 
# E.g.:
screeningRound:     50  Mammo 
screeningRound:     52  Mammo 
screeningRound:     54  Mammo 
screeningRound:     56  Mammo 
screeningRound:     58  Mammo 
screeningRound:     60  Mammo 
screeningRound:     62  Mammo 
screeningRound:     64  Mammo 
screeningRound:     66  Mammo 
screeningRound:     68  Mammo 
screeningRound:     70  Mammo 
screeningRound:     72  Mammo 
screeningRound:     74  Mammo 

# supported distribution names are: Normal, LogNormal, Uniform, Exponential
# screening         value   distribution:
systematicError:    0       Normal  
attendanceRate:     0.8     Normal  

#                                   bi-rad classification
#                               ----------------------------
#                   agegroup     a       b       c       d
breastDensities:    0  - 40     0.05    0.30    0.48    0.17
breastDensities:    40 - 50     0.06    0.34    0.47    0.13
breastDensities:    50 - 60     0.08    0.50    0.37    0.05
breastDensities:    60 - 70     0.15    0.53    0.29    0.03
breastDensities:    70 - *      0.18    0.54    0.26    0.02


# Modalities:

Mammo cost: 64   
#     bi-rad cat:   a       b       c       d             
Mammo dose:         3       3       3       3  
#                   agegroup
Mammo specificity:  0 - 40:  0.961     40 - *: 0.965
#                   1              2             3             4             m
Mammo beta:         -4.38 Normal   0.49 Normal  -1.34 Normal  -7.18 Normal   0.136 Normal


Tomo cost: 64   
#    bi-rad cat:    a       b       c       d             
Tomo dose:          3       3       3       3  
Tomo sensitivity:   0.87    0.84    0.73    0.65   
#                   agegroup
Tomo specificity:   0 - 40:   0.961     40 - *: 0.965

MRI cost:           280
MRI sensitivity:    0.94
MRI specificity:    0.95
                    
                        
# TUMOR incidence parameters:
#                                       lifeTimeRisk            meanAge             stdandardDeviation
#               carier                  ---------------------   -----------------   ----------------------
#               name    probability     value  spread   dist.   value spread dist.  value   spread  dist.   
tumorIncidence: Normal  1               0.226  0.0053   Normal  72.9  0.552  Normal 21.1    0.048   Normal  
tumorIncidence: BRCA1   0               0.96   -        -       53.90 -      -      16.51   -       -       
tumorIncidence: BRCA2   0               0.96   -        -       53.90 -      -      16.51   -       -       
        
# Tumor growth model parameters
#               startDiameter           selfDetectDiameterMu        selfDetectDiameterSigma
#               --------------------    --------------------        -----------------------
#               value   spread  dist.   value   spread  dist.       value spread dist.     
tumorGrowth:    5       0       Normal  2.92    0.084   Normal      0.70  0      Normal  
                
#doublingTime:  agegroup        mean spread  dist.      stdev   spread  dist.
tumorGrowth:    1-50            4.38 0.43    Normal     0.61    0       Normal  
tumorGrowth:    50-70           5.06 0.17    Normal     0.26    0       Normal  
tumorGrowth:    70-100          5.24 0.23    Normal     0.45    0       Normal  
        
#       b       e       spread  dist. 
beir7:  0.51    -2.0    0.32    Normal  
    
#            (e.g., CumTumorDeathProb.txt)
#               type    value       spread      dist:
tumorSurvival:  a       0.00004475  0.000004392 Normal  
tumorSurvival:  b       1.85867     0.0420      Normal
tumorSurvival:  c       -0.271      0.0101      Normal
tumorSurvival:  d       2.0167      0.0366      Normal




